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PMCID: PMC5844662

doi: 10.1038/s41416-023-02149-6 86 TopalianSLHodiFSBrahmerJRGettingerSNSmithDCMcDermottDFet al

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Glutathione measurement in human plasma: evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC

Pharmacokinetics vs pharmacodynamics ADME studies in late discovery support the planning for toxicology as well, with predictions of potential metabolic liabilities, differences in cross-species metabolism, and potentials for drug-drug interactions

The findings indicated that AST/Bex treatment restrained transcription and activity of the amyloidogenic enzyme BACE1, consequently decreasing A oligomers as well as 80-kDa intracellular APP/A species