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When caloric intake decreases, the body compensates by slowing metabolism and increasing hunger signals, making sustained weight loss difficult for many individuals

94% reduction in progression from pre diabetes to type 2 diabetes with tirzepatide.** **Based on a three-year clinical trial study (176-week treatment period) sponsored by Eli Lilly and Company, weekly injections of tirzepatide significantly reduced the risk of progression to type 2 diabetes by 94% in adults with prediabetes who were overweight or obese compared to placebo

References Hilger, D., Masureel, M

2018;8:726 elik Tekeli M, Yaln Y, Verdi H, Akta Y, elebi N

Medicare prescription plans do not cover weight-loss medications, although they often cover Wegovy and Zepbound for other FDA-approved purposes, such as treating obstructive sleep apnea (Zepbound) or lowering the risk of major cardiovascular events (Wegovy)

The attenuation of effect with tachyphylaxis primarily reduces the delay in gastric emptying, with long-acting formulations showing less consistent slowing of emptying compared to short-acting agents
