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In contrast to larger molecules that are actively transcytosed by enterocytes to permit their access beyond the intestinal epithelium, the translocation of smaller molecules occurs via several different paracellular routes (Fine et al

To generate DIDO and RBM15 SPOC-deleted cell lines, two gRNAs targeting the flanking region of the SPOC domain (DIDO: 5-GGGTCGTGTCTCCCTCTGGA-3 and 5-CCAAGAATTATATTCGGACG-3

The results showed that the senescenceassociated galactosidase activity the protein expression of P16 AND P21, and inflammatory-related marker gene levels IL-1, IL-6, and TNF- were increased in bleomycin-treated AFSCs in a dose-dependent manner