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In addition, there are some potential benefits that occur regardless of the amount of weight lost, suggesting that there could be something about the medications that are providing protective properties on their own like improvement in cardiovascular health

Firstly, we specifically investigated a low dose of semaglutide that did not induce significant weight loss, and therefore, our findings do not directly address the potential additive or synergistic benefits that might be observed with higher, weight loss-inducing doses of the drug

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were reviewed and approved by the local (Comit rgional dthique de Midi-Pyrnes) and national (Ministre de lEnseignement Suprieur et de la Recherche) ethics committees (protocol number 0504906)