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and 3) Iron deficiency possibly affects macrophage function in marrow causing delayed extrusion of the nucleus of erythroid progenitors so they cannot be released from marrow (a protein in erythroblasts called erythroblast macrophage protein is required for their interaction with macrophages and extrusion of their nuclei

Polyphenols may have biological effects besides their antioxidant action, such as encouraging good gut bacteria, enhancing blood sugar regulation, and promoting healthy aging processes (161)

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