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6+ months Significant weight reduction, often 1520% of body weight when combined with lifestyle changes

And, for those wondering, yes, they work

Nguyen, PA

Importantly, lipedema fat has historically been considered resistant to weight loss interventions, raising questions about whether GLP-1-induced weight reduction affects lipedema tissue differently than conventional caloric restriction

The [pre-] history of the incretin concept

consulting fees from Altimmune, Amgen, ApStem, Aqua Medical, AstraZeneca, Boehringer-Ingelheim, CeQur, Corcept Therapeutics, Dexcom, Eli Lilly, embecta, GentiBio, Glyscend, Insulet, Medtronic MiniMed, Mellitus Health, Metsera, Novo Nordisk, Pendulum Therapeutics, Praetego, Stability Health, Tandem, Terns Inc., Vertex Pharmaceuticals, and Zealand