glp-1 drugs and autoimmune disease glp 1 How Receptor Agonists Evolved from Diabetes to Weight Loss Treatments GLP-1 Drugs: Ozempic, Mounjaro, Zepbound:

Most important of these was Novo Nordisk demonstrating in a 17,000 patient five year clinical trial that Wegovy reduced the risk of major cardiovascular events (MACE) by 20%

Clinical and experimental studies demonstrate that GLP-1RAs decrease hepatic fat content and fibrosis markers, reduce circulating pro-inflammatory cytokines, and promote favorable adipokine profiles, collectively dampening immune activation [9,25]

Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration

Food and Drug Administration (2017)

PLoS One 9:e89881

Theres still a big gap in our understanding, Rasouli said