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Liraglutide, a GLP-1 receptor agonist, improves weight and glycaemic control in patients with T2DM

These trials have enriched the therapeutic landscape for T2D patients, offering a range of GLP-1 receptor agonists with varying cardiovascular profiles, thus allowing clinicians to personalize treatment for each patient

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CMS has said it will release more detail on how the two programs interact during the 2027 demonstration period

GEP44 was developed based on extensive structureactivity relationship studies and earlier preliminary in vivo studies that demonstrated its greater efficacy at reducing both food intake and body weight compared to the agonist peptide, Ex-4, without triggering gastrointestinal distress (as assessed by kaolin intake and behavioral scoring as a proxy for nausea in rats and direct evidence of emesis in shrews) 16
