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However, the level of DNA adducts was significantly lower in the pancreas compared to the lung explaining, at least partially, why a higher level of DNA mutations is observed in the lung of humans and animals exposed to cigarette smoke compared to the pancreas (13)

doi: 10.1165/rcmb.2008-0301OC

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That makes them narrower, and it makes it more difficult for your heart to pump blood through them
