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Description
A common dosing approach begins with 0.25 mg once weekly, with stepwise increases until reaching the maintenance dose of 2.4 mg once weekly, as directed by your healthcare provider
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This results in a pronounced increase in the intratumoral interstitial fluid pressure (IFP), 16 forming an IFP gradient that favors the flow of interstitial fluid from tumors through the surrounding stroma and into areas of lower IFP, thereby enabling tumor cells and tumor-derived compounds to more readily access LNs

Jones, B., et al

doi: 10.1152/ajpendo.00445.2011

Smaller, more frequent meals tend to feel better and support steadier nutrient intake throughout the day
