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While earlier versions of the Diagnostic and Statistical Manual of Mental Disorders (DSM) used the term dependence to describe the mental health syndrome caused by problematic tobacco use, DSM-5 no longer uses the term dependence and now uses tobacco use disorder, which includes many of the symptoms previously identified for the DSM-IV nicotine dependence disorder

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7 who reported nausea and gastric burning as common gastrointestinal symptoms among nicotine users, highlighting the gastrointestinal side effects associated with nicotine

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These researchers used bio-marker studies to compare relative harm