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Med Res Rev 39(6):25052533 Losada-Barreiro S, Sezgin-Bayindir Z, Paiva-Martins F, Bravo-Daz C (2022) Biochemistry of antioxidants: mechanisms and pharmaceutical applications

2006Circulation Research

Transcriptome studies in the heart and liver further confirmed that chronic stress induces broader reprogramming (2,503 and 2,236 DEGs, respectively) compared to acute stress (1,217 and 1,843 DEGs, respectively), with conserved upregulation of HSP genes ( HSP90AA1 , HSPA4 , HSPB8 ) and antioxidant genes ( GPX1 ), while tissue-specific adaptations involved immune signaling in the heart and metabolic remodeling in the liver [57]

This comprehensive and in-depth understanding will provide comprehensive support for the design and development of nano-delivery systems and will promote the further innovation and application of nanotechnology in biomedicine, drug delivery, and other fields