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, 2024), and the study by Hanif et al

Starting with a lower dose and gradually increasing may help minimize side effects

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Approximately half of all the animals in this study (60% dogs, 41% cats) had class II obesity, with the proportion remaining relatively stable over time in dogs but not cats, where the prevalence between 2014 and 2017 was greater than the prevalence between 2009 and 2013

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Accordingly, HIF-1 accumulation was also abrogated upon PI3K/mTOR inhibition, further demonstrating its importance for the observed metabolic adaptations (Fig