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As tirzepatide mimics the effects of two hormones, its perhaps not surprising that research trials have found it to be more effective than semaglutide, which only acts on GLP-1

The group, co-corresponding authors Andrew Lutas at NIDDK and Michael Krashes also at NIDDK, used a fluorescence indicator to watch intracellular cAMP rise and fall in living brain slices from mice

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Additionally, GLP-1 receptors have been identified in various tissues involved in inflammation and immune regulation, raising questions about potential anti-inflammatory effects that could theoretically benefit the chronic inflammatory component of lymphedema