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Pathogenic processes lead to ALS neurodegeneration, including mitochondrial dysfunction, apoptosis, chronic inflammatory reactions mediated by cytokine production, free radical generation, decreased neurogenesis, synaptic loss, synaptic death, excitotoxicity, axonal transport impairment, and neurotrophic factor dysregulation [137]

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Abstract Despite Polycystic Ovary Syndrome (PCOS) is a very prevalent disorder among women of reproductive age, there is widespread agreement that until now, no pharmacological options are available to tackle the entire spectrum of clinical manifestations encountered in the clinical practice

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