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In animal models, the co-deletion of LRP5 and LRP6 resulted in severe local and global bone loss in mice (Lim et al., 2021)

Murugesan S, Gowramma B, Lakshmanan K, Karri VV, Radhakrishnan A

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The GLP-1 receptor was first identified by ligand binding experiments and measurements of cyclic AMP accumulation using the rat insulinoma cell line

Myostatin knockout in mice increases myogenesis and decreases adipogenesis