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Also, due to the important role of endothelial dysfunction in CVD, the effects of GLP-1RA on flow-mediated vasodilation (FMD) in patients remain to be investigated for their contribution to the CVD actions of GLP-1RAs

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species

But a 2017 review of commercially available glutenases found that several products failed to adequately degrade the toxic gluten peptides, leaving immunogenic sequences intact.46 The authors concluded these products could be a potential hazard in celiac disease because they might encourage people to relax their gluten-free diet without actually preventing intestinal injury

Since its initial approval for weight loss, its also been approved to reduce cardiovascular risk and treat a liver disease called MASH (metabolic dysfunction-associated steatohepatitis)
