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This retrospective, observational study assessed persistence and adherence in patients with type 2 diabetes (T2D) initiating once-weekly or daily injectable glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in US clinical practice

Methods A pooled post hoc analysis of 11 randomized clinical trials (N = 4595) of 1030 weeks duration from the exenatide once-weekly (QW) development program evaluated heart rate with exenatide QW (intervention group) and exenatide twice daily (BID), liraglutide, and non-GLP-1RAs (insulin, metformin, pioglitazone, and sitagliptin) (comparison groups)

Although it has been in use for a few years now and has led to some impressive weight-loss results, it is likely that most Saxenda users will change to the once-weekly Wegovy

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The Role of Amino Acid Substitutions Single amino acid changes can significantly influence how strongly an antibody binds to its target