glp-1 weight loss overview NYC Why GLP-1 Drugs Alone Aren't

Insufficient/not enough sleep and stress are key dysregulators of weight, insulin sensitivity and inflammation in the body, all things we are trying to optimize with GLPs

Analysis from the Bariatric Outcomes Longitudinal Database showed that of the 3,318 patients with insulin-treated T2D who underwent RYGB, 62% could discontinue insulin at 12 months [82]

However, the prescribing information specifies important limitations

Similar to other antidiabetic medications, such as metformin [40], and in combination with diet and exercise, the reduction in insulin resistance induced by GLP-1 RAs may help reduce or resolve AN

An injectable hydrogel system, Diabogel, has been developed using alginate and 3-aminophenylboronic acid to deliver modified GLP-1, islet-derived extracellular vesicles, and telmisartan

Semaglutides extended-release (ER) formulation provides a prolonged half-life compared to short-acting GLP-1 RAs, supporting once-weekly dosing regimens and enhancing patient adherence (23)(32)