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Published 25 May 2026 Reading time 16 minutes Last reviewed 25 May 2026 TRIUMPH-1 Phase 3 n = 2,339 "The largest weight loss ever observed for a non-surgical obesity treatment" 28.3% Average body weight loss (12 mg, 80 weeks) 30.3% Average weight loss (BMI 35 extension, 104 weeks) 45.3% Of 12 mg participants past the 30% threshold 24.1 cm Average waist circumference reduction at 12 mg The 30-second version What happened: On 21 May 2026, Eli Lilly published topline TRIUMPH-1 Phase 3 results for retatrutide
Patients are usually instructed to attach a new sterile needle for each injection
Side effects typically become less bothersome or resolve entirely
Liu Z-Z, Duan X-X, Yuan M-C, Yu J, Hu X, Han X, et al
Global analyses similarly indicate that GLP-1 RAs remain substantially more accessible in diabetes care than in obesity care, reflecting reimbursement structures, variable professional familiarity, and weight-related biases in clinical pathways [88]
