glp-1 better tolerated ozempic vs alternatives Medications: Is the Best Option for You? Is GLP-1 Safe for Weight
Description
Ozempic mimics the effects of natural GLP1 but with a few critical enhancements
This GLP-R1 agonist seems to increase oncogenesis in multiple tissues, including the thyroid, bladder, pancreatic, and colorectal [97, 110, 121]
10.1186/s13098-023-01118-6 131 YunC.YanS.LiaoB.DingY.QiX.ZhaoM.et al (2024)
This phenomenon, known as the Warburg effect [28, 29], is attributed to damaged mitochondria in cancer cells
GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)
Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration
