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While these adverse effects may be rare, their severity has triggered increased regulatory attention and expanding litigation

Recent research has also associated long-term GLP-1 drug use with an increased risk of vision problems

doi: 10.1210/en.2013-1447

This can quickly lead to a state of chronic low-level dehydration

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In GLP-1 (737) NH 2 , both the affinity and activity are slightly promoted when Val 16 is replaced with Tyr 16