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doi: 10.1111/dom.v26.11 62 ParkJNtelisSYunasanEDowntonKDYipTCMunirKMet al

Semaglutide and tirzepatide were FDA-approved in 2021 as injectable treatments for weight loss, under the names Wegovy and Mounjaro

Newer diabetes medications like GLP-1 receptor agonists (Ozempic, Mounjaro) seem to promote the most weight loss, while oral drugs like metformin and SGLT2 Inhibitors (Jardiance) tend to lead to more modest outcomes for weight

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Coupling of Gs and Gq in beta cells of pancreas lead to an increase in cAMP by activation of adenylyl cyclase and phosphoinositol 3 kinase (PI3K) pathway

Zinman et al., 2018)