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Developing a stable bilateral model of parkinsonism in rhesus monkeys
Dose-related GI symptoms during the rapid titration phase are a well-documented cause of patients quitting GLP-1 therapy (source)

specifically, cholelithiasis (RR, 1.27

Therefore, given the rarity of suicidal or self-harming behaviors, the limited sample size of the RCT, and the inherent limitations of retrospective studies, comprehensive research with long-term follow-up and rigorous mental health assessments is needed to clarify the potential risks and benefits
