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The Impact of the Treatments on the Response of -enriched Genes and Proteins In the second part of this study, we investigated the responses of genes and proteins associated with -cell identity, including Ins1 , Ins2 , Pdx1 , Slc2a2 , MafA , NeuroD1 , and Foxo1 mRNA, as well as PDX-1, FOXO1, and NKX6.1 proteins, to 1 mM metformin, 10 nM semaglutide, and the combination of 1 mM metformin and 10 nM semaglutide (MS)

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