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Some people find that smaller, more frequent doses produce better appetite suppression with fewer GI symptoms than standard once-weekly dosing
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Pancreatitis risk Pancreatitis, inflammation of the pancreas, has been a concern with all incretin-based therapies since the earliest GLP-1 drugs reached market

GLP-1 medications can suppress appetite and worsen gastrointestinal symptoms, increasing the risk of malnutrition or sarcopenia issues already prevalent in older CKD patients

For diabetes management, tirzepatide is indicated as an adjunct to diet and exercise to improve glycemic control in adults
