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en estudios iniciales fase II en pacientes con diabetes y obesidad se observaron reducciones significativas de HbA1c junto con prdida de peso

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These studies are conducted using controlled in vitro and in vivo models to better understand receptor activation, downstream signaling cascades, and peptide stability

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The results prompt safety concerns for GLP-1RAs, especially with high dose administration, regarding gastrointestinal adverse events
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