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Wegovys weekly injection and similar pricing to Saxenda led to an overwhelming market response, causing supply issues

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These medications, which include Novo Nordisks semaglutide, sold as Ozempic and Wegovy, and Eli Lillys tirzepatide, sold as Zepbound and Mounjaro, are not recommended for use during pregnancy because their safety for the fetus is unknown and animal studies have suggested potential risks

Eli Lilly's CEO, David Ricks, commented on this issue during an investor meeting: "We are witnessing unprecedented demand, but with that comes an immense responsibility to ensure that our manufacturing and distribution capacities can meet the needs of millions of patients worldwide

During obesity, pro-inflammatory macrophages accumulate in adipose tissue representing a chronic low-grade inflammation

For a deeper look at that pharmacology, our guide to why GLP-1 dosing frequency differs explains the role of half-life in weekly dosing