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Tirzepatide is FDA-approved (for diabetes and weight loss, depending on the brand) and works as a dual-agonist, targeting GLP-1 and GIP receptors to reduce appetite, improve insulin response, and support weight loss

An argument can be made for early treatment in borderline cases, especially in patients with the identified high-risk characteristics for retinopathy progression with GLP-1/GIP agonist use ( Table 2 )

Initially, ulcers look like pink or red craters that ooze fluid or more rarely bleed

Clinical Implications Reaching steady state has important clinical implications

Nausea and gastrointestinal discomfort, when they occur, are most commonly reported during this early escalation phase

Front Endocrinol (Lausanne) (2014) 5:140