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And indirect costs from productivity losses are borne by the employer

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Kim, J., & Park, S

Over-the counter medications Patients with sleep-onset insomnia have traditionally taken sedating antihistamines (diphenhydramine and doxylamine) to hasten sleep onset, but they quickly induce tolerance, and often leave the patient sleepy or less alert the next morning as well

Once-weekly dosing therefore produces sustained drug concentrations that are an order of magnitude or more above physiologic baseline

The key difference is that compounded versions are prepared in smaller batches by licensed 503A pharmacies rather than mass-produced by large manufacturers