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In an 18-month clinical trial of the experimental GLP-1 pill orforglipron, about 60 percent of people lost at least 10 percent of their body weight.

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Backed by more than five years of real-world clinical data, Calibrate members achieve an average of 18% weight loss at one year and sustain these results over the long term, far exceeding outcomes from medication alone
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Discover what clinical evidence reveals about GLP-1 receptor agonists and thyroid cancer risk, who should exercise caution, and essential safety guidance for UK patients.
