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Conclusions GLP-1 agonists reduce fetal survival, weight, growth and skeletal ossification and can induce major congenital anomalies

Data from numerous clinical trials primarily evaluating the antihyperglycemic effects of multiple GLP-1 RAs have also revealed that changes in most CVD risk markers reported as secondary outcomes have been in favor of GLP-1 RAs treatment

Glucose-lowering treatments and COVID-19 mortality in T2DM

Many patients find the weekly injection more convenient once they get past the initial apprehension about self-injection

However, the half-life of GLP-1 is too short at 1 to 2 minutes, making it difficult to use as a drug [21]

In both cases, the presence of anti-drug antibodies was not correlated with relevant hypersensitivity events