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This led to the first approved GLP-1 receptor agonist, exenatide (Byetta), in 2005 which binds to the same receptor but works far longer

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Incretin-based therapies Incretins are hormones that are secreted from enteroendocrine cells in the gut mucosa after a meal

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In murine pancreatic Min6-K8 cells, prevention of cytosolic glutamate production by KO of a key component of the malate-aspartate shuttle or triple KO of the vesicular glutamate transporters Slc17a6, Slc17a7, and Slc17a8 impaired GLP-1-induced insulin secretion [515]