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Endocrinology (1998) 139:40047

GLP-1RAs aid in weight loss by regulating the gut-brain axis and interacting with leptin, while weight loss can alleviate the harmful effects of obesity on the body, particularly in knee OA, by reducing joint loading and inflammation

GLP-1 RA: glucagon-like peptide 1 receptor agonist

Microbiota depletion impairs thermogenesis of brown adipose tissue and browning of white adipose tissue

The review encompassed six studiestwo randomized controlled trials and four observational investigationstotaling over 88,000 participants

Problems with this type of study include selection bias and confounding variables