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Patients with non-neuropathic MPS II experience normal cognitive and intellectual development, although other organ systems are affected and retinal degeneration and neurological symptoms may appear in advanced disease

The leading hypothesis to reconcile these findings is the early worsening phenomenon, where rapid and substantial glycemic improvement temporarily exacerbates pre-existing DR

The trial was double-blinded, meaning neither the investigators nor the persons with Parkinsons were made aware of who was actually receiving an active drug (rather than a placebo/inactive drug)

For these users, the nasal spray offers a practical way to examine endocrine function markers over time without the discomfort and complexity of injectable options