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Curious to learn more about the effect of GLP-1 on appetite, in 1998 Holst and collaborators at the University of Copenhagen undertook a placebo-controlled, randomised study with 20 healthy young men between the ages of 20 and 31

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One pharmacokinetic study showed a modest bioavailability of only 0.8 percent for oral semaglutide, meaning less than one percent of the drug is absorbed into the blood where it can take effect

Realistic expectationsmodest rather than dramatic lipid changessupport sustainable treatment outcomes