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Other factors are the influence of diabetic cardiomyopathy (DM-induced cardiac remodeling resulting in diastolic and/or systolic dysfunction) [21], genetic and epigenetic modifications [22], and the possible adverse effect of hypoglycemic agents

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[17] [18] Therefore, the combination should not be used with the expectation of enhanced cardiovascular protection

doi: 10.1073/pnas.93.15.7911

World J Diabetes 2014;5:901-4.ArticlePubMedPMC 56

doi: 10.1038/nprot.2012.044