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Biochem Biophys Res Commun 384(2):259264

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While human data on pathophysiological regulation of these proteins is largely missing, Interleukin-6 13 and bile acids 14 were identified as stimulators besides the classic L-cell activators

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As a result, potential safety concerns might arise in everyday clinical practice that were not evident during the more controlled and structured environment of clinical trial evaluations [Reference Paludetto, Olivier-Abbal and Montastruc28]