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Insulin resistance, the hallmark metabolic derangement of obesity, directly impairs endothelial NO synthase (eNOS) activity

These medicines include orlistat, phentermine and topiramate, and naltrexone/bupropion)

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These improvements may be due to better body image, increased self-esteem, and hormonal changes associated with weight loss

The Journey Card records progress photos and measurements so you can spot healthy trends like preserved muscle mass and improved body composition

What makes this study particularly compelling is that it also provides new insight into how this class of drugs may influence the brains reward system, says Christian Edvardsson, a doctoral student in pharmacology at the Sahlgrenska Academy, University of Gothenburg