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Comparatively, PEGylation offers superior control over immunogenicity and is more amenable to integration into multifunctional nanocarriers for targeted or stimuli-responsive delivery

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Emerging technologies to achieve oral delivery of GLP-1 and GLP-1 analogs for treatment of type 2 diabetes mellitus (T2DM)
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First up is a veggie option from The Ultimate GLP1 Cookbook by Christina Jordan
42 Research has shown that GLP-1RA can trigger the AMPK pathway, resulting in anti-inflammatory outcomes
Comparable to other peptides linked to fatty acids (e.g., the insulins detemir and degludec, the GLP-1RA liraglutide and semaglutide), the fatty acid side chain allows binding to albumin after subcutaneous injection, slows enzymatic degradation and prolongs biological half-life (5760)
