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There have been and continue to be advances in the GLP-1 pipeline.

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However, some patients do report irritability, which is most often related to indirect factors such as under-eating, blood sugar fluctuations, sleep disruption, or changes in reward signaling rather than the medication itself.This post explains the science behind these effects, identifies who may be more vulnerable, and outlines practical strategies clinicians and patients can use to reduce risk

Compared with liraglutide alone, the combined treatment decreased time to complete a stair climb test by 1.2 s [95% confidence interval 0.61.9] (corresponding to 8.6%) and improved peak oxygen consumption by 3.0 mL/min/kg fat-free mass [95% confidence interval 0.55.5]

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