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As of 28 October 2024, the UK Government's med watch database (MHRA) received over 7,000 reports of gastrointestinal side effects linked to GLP-1RAs, with some resulting in hospitalization

The proportion of muscle loss relative to fat loss depends on several factors, including the rate of weight loss, protein intake, physical activity levels, and the individual's starting body composition

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Common side effects include nausea, vomiting, diarrhoea, and abdominal discomfort

The compounded GLP-1 drug debate isnt quite over

Contrave is not appropriate for patients with seizure disorders (bupropion lowers the seizure threshold), eating disorders such as bulimia or anorexia, current opioid use or opioid dependence (naltrexone blocks opioid receptors), uncontrolled hypertension, patients taking MAO inhibitors, or women who are pregnant or planning to become pregnant