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IntroductionThe surge in prescribing glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for diabetes and weight management highlights a pressing need to c...

The angiopoietin-like (ANGPTL) proteins are now recognized as critical regulators of the harmful changes seen in diabetic kidney disease

Further pharmacovigilance and mechanistic studies are warranted to clarify this potential association.

However, 3D variability analysis of the cryo-EM micrographs revealed different motions within the bound peptides and the receptor relative to when GLP-1 is bound
