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22 The Standing Challenge: The court initially ruled against Novo Nordisk on certain claims, reiterating that private parties cannot sue to enforce the FD&C Act

Martin SS, Aday AW, Almarzooq ZI, et al

Fact: Leg Pain and GLP-1s Myth: Ozempic directly causes permanent nerve damage in the legs

doi: 10.1016/0016-5085(93)90640-X

Newer medications such as tirzepatide (a dual GIP/GLP-1 receptor agonist) have shown promising efficacy in clinical trials, though UK availability for weight management is subject to regulatory approval and NICE assessment

For example, a patient with type 2 diabetes on GLP-1 scheduled for hip replacement may continue the agent until 1 to 2 weeks pre-op if weight loss is modest, but stop earlier if gastroparesis or severe nausea is present