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doi: 10.1002/oby.21577 [DOI] [PMC free article] [PubMed] [Google Scholar] 243

Peripherally acting anti-obesity medicines with evidence for use in older adults Orlistat Weight loss trials None of the XENDOS trial participants were older adults, and hence the results from this study may not be applicable to an ageing population, although as the drug works peripherally there is no reason to suggest reduced efficacy or safety in elderly patients
If the body gets used to the medicine gradually, these side effects may not be as strong

Headaches : Hormonal birth control can trigger headaches or migraines in some people, especially around the time of their period
Another study found that eating a whole avocado with a meal increased GLP-1 levels while also reducing insulin levels

Whats interesting is that retatrutide is being trialled as a once-a-week injection, which could make it easier for users to maintain long term
