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CPAA (2022) 14:1926

To make firmer conclusions, additional clinical trials designed around revealing cardiovascular benefits should be conducted

While preclinical and clinical studies have reported anti-metabolic and anti-inflammatory benefits with a favourable safety profile, further evidence from long-term and large-scale trials is necessary to guide clinicians in real-life scenarios

For NYC patients approaching Medicare or already enrolled in Part D, this may become an important bridge between todays uneven obesity-drug coverage and broader future access

A Rotterdam study has shown that the risk of AD in patients with T2MD is increased by 2-fold (42)

The glucose-lowering efficacy measured by the decrease in HbA1c was dose-dependent in the tirzepatide group and did not plateau [52]