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Description
The Phase 2 trial data published in 2023 (Jastreboff et al., NEJM) included cardiovascular safety monitoring as a secondary endpoint

Forest plot of GLP-1 receptor agonists versus comparators on the risk of Pulmonary fibrosis

The short answer is cost -- even at a negotiated price of ~$245/mo, the model would have made these drugs available to millions of Medicare beneficiaries, and the costs would have added up quickly

Why Might Nightmares Happen

doi: 10.1136/bmj-2020-054370

The result is one injection that delivers both your weight loss medication and a vitamin that your body increasingly needs while taking it
