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These NMR data are in line with ligand-bound GLP-1R ECD crystal structures showing that the GLP-1 is a kinked but continuous -helix (Thr 13 Val 33 ), whereas the truncated exendin 939 is a straighter helix (Leu 10 -Lys 27 ) than GLP-1 when bound to GLP-1R (Runge et al., 2008

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