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(viii) improve mitochondrial dysfunction that has been associated with IR and (ix) achieve -cell function preservation (both in patients with T2D and individuals with prediabetes) and suppress excess intra-pancreatic fat deposition [44, 45, 5764] (Figure 1)

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Whilst these medications offer substantial metabolic benefits, their use has raised questions about potential adverse effects, including impacts on gallbladder health

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Use of peptide-based metabolic therapies must follow ethical, regulatory, and safety frameworks

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