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Glucagon-like Peptide-1 receptor agonists and suicidal ideation: analysis of real-word data collected in the European pharmacovigilance database

However, researchers have noted that the "GIP-heavy" profile of Retatrutide and Tirzepatide may actually blunt some of the more severe emetic effects seen with pure GLP-1 agonists

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These are almost always dose-dependent and improve as your body adjusts

When to Seek Medical Care for Mounjaro-Related Diarrhea Most diarrhea is mild, but get prompt care if you have any of the following: More than four stools per day Worsening diarrhea over time Stomach pain with diarrhea Blood in stool Inability to eat or drink Dizziness or lightheadedness when standing Chest pain or rapid heartbeat Making less urine than usual Urine that looks darker than normal Fainting Call your healthcare team right away if these occur so they can check for dehydration or other complications